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simbiology platform  (MathWorks Inc)
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MathWorks Inc simbiology platform
Parametric Sensitivity Analysis Showing the Influence of Model Parameters on Ago2 Depletion Sensitivity analysis carried out for all the model parameters, using the <t>Simbiology</t> toolbox in MATLAB. The bar graphs show the consolidated sensitivity metrics of Z (Ago2 depletion) with respect to model parameters. Parameters ranked from highest to lowest impact are as follows: endosomal escape (b), cell entry (a), siRNA-Ago2 loading (d), and degradation of siRNA in the cytoplasm (e). The other parameters did not seem to have an effect on Ago2 loading.
Simbiology Platform, supplied by MathWorks Inc, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Parametric Sensitivity Analysis Showing the Influence of Model Parameters on Ago2 Depletion Sensitivity analysis carried out for all the model parameters, using the Simbiology toolbox in MATLAB. The bar graphs show the consolidated sensitivity metrics of Z (Ago2 depletion) with respect to model parameters. Parameters ranked from highest to lowest impact are as follows: endosomal escape (b), cell entry (a), siRNA-Ago2 loading (d), and degradation of siRNA in the cytoplasm (e). The other parameters did not seem to have an effect on Ago2 loading.

Journal: Molecular Therapy. Nucleic Acids

Article Title: Modeling the Kinetics of Lipid-Nanoparticle- Mediated Delivery of Multiple siRNAs to Evaluate the Effect on Competition for Ago2

doi: 10.1016/j.omtn.2019.03.004

Figure Lengend Snippet: Parametric Sensitivity Analysis Showing the Influence of Model Parameters on Ago2 Depletion Sensitivity analysis carried out for all the model parameters, using the Simbiology toolbox in MATLAB. The bar graphs show the consolidated sensitivity metrics of Z (Ago2 depletion) with respect to model parameters. Parameters ranked from highest to lowest impact are as follows: endosomal escape (b), cell entry (a), siRNA-Ago2 loading (d), and degradation of siRNA in the cytoplasm (e). The other parameters did not seem to have an effect on Ago2 loading.

Article Snippet: The mathematical model presented in was simulated, using the Simbiology platform developed by MathWorks and modeled, using a system of differential equations, as shown in the Results section.

Techniques: